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Токсикология

Frank C. Lu, Sam Kacew, "Lu's Basic Toxicology: Fundamentals, Target Organs, and Risk Assessment, Fifth Edition"
English | 2009 | ISBN: 1420093118, 1420093150 | 408 pages

Decades of research and teaching experience are compiled in the authoritative and highly awaited new edition of this classic text. For the utmost in reader convenience and comprehension, Lu's Basic Toxicology uses easy-to-understand terminology, and separate subject and chemical indexes.

Providing clarity and insight into this rapidly evolving subject, this guide provides new information on:

over-the-counter preparations
lactation
occupational toxicology

Written by two key opinion leaders in toxicology, this text also covers the essentials of:

why chemicals target specific organs and systems, and commonly used procedures for assessing risk associated with these chemicals
chemicals that cause: cancer, mutations, congenital malformations, and organ or system specific effects
host and environmental factors that modify the effects of specific chemicals, including: food additives; pesticides; metals; pollutants in air, water, and soil; and toxicants encountered in workplaces

"Color Atlas of Human Poisoning and Envenoming"
Publisher: CRC Press | ISBN: 0849322154 | edition 2006 | 558 pages

The Color Atlas of Human Poisoning and Envenoming is the only full-color resource available for the immediate visual association and the rapid identification of envenoming species, resultant lesions, clinical outcomes of envenoming or poisoning, and recommended treatment strategies to limit toxic exposures and injuries. With no-nonsense, bulleted text, tables, figure legends, and diagrams, this atlas provides an immediate reference for use in emergency differential diagnosis.

James M. Parry, Elizabeth M. Parry - Genetic Toxicology: Principles and Methods
Published: 2011-12-07 | ISBN: 1617794201 | 449 pages 

The evaluation of potential mutagenic activity is a critical step in the assessment of the safety of both new and pre-existing chemical types. In Genetic Toxicology: Principles and Methods, expert contributors help to satisfy the demand for education in this tremendously important area of study. The volume covers three basic areas: the scientific basis of the discipline, the methodologies of the main test assays, and the application of the methods, all aimed primarily at scientists in the safety departments of the industries working with both natural and synthetic chemicals. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Intuitive and cutting-edge, Genetic Toxicology: Principles and Methods provides crucial support to both laboratory workers in providing quality information on the appropriate application of techniques and to study directors in their assay selection and protocol design in this vital field.

Saura C. Sahu, "Toxicology and Epigenetics"
English | ISBN: 111997609X | 2012 | 688 pages

 Epigenetics is the study of both heritable and non-heritable changes in the regulation of gene activity and expression that occur without an alteration in the DNA sequence. This dynamic and rapidly developing discipline is making its impact across the biomedical sciences, in particular in toxicology where epigenetic differences can mean that different individuals respond differently to the same drug or chemical.

Toxicology and Epigenetics reflects the multidimensional character of this emerging area of toxicology, describing cutting-edge molecular technologies to unravel epigenetic changes, the use of in vivo and in vitro models, as well as the potential use of toxicological epigenetics in regulatory environments. An international team of experts consider the interplay between epigenetics and toxicology in a number of areas, including environmental, nutritional, pharmacological, and computational toxicology, nanomaterials, proteomics and metabolomics, and cancer research.

Topics covered include:
environment, epigenetics and diseases
DNA methylation and toxicogenomics
chromatin at the intersection of disease and therapy
epigenomic actions of environmental arsenicals
environment, epigenetics and cardiovascular health
toxicology, epigenetics and autoimmunity
ocular epigenomics: potential sites of environmental impact in development and disease
nuclear RNA silencing and related phenomena in animals
epigenomics – impact for drug safety sciences
methods of global epigenomic profiling
transcriptomics: applications in epigenetic toxicology

Toxicology and Epigenetics is an essential insight into the current trends and future directions of research in this rapidly expanding field for investigators, toxicologists, risk assessors and regulators in academia, industry and government.

Kevin Woodward, "Toxicological Effects of Veterinary Medicinal Products in Humans: Volume 1"
2013 | ISBN-10: 1849734178 | 500 pages

 Toxicological Effects of Veterinary Medicinal Products in Humans is the first definitive guide to discuss the adverse effects of veterinary medicinal products in humans. The chapters focus on occupational safety and consumer issues and examine the circumstances under which exposure is likely to occur. To be in context, it reviews this against the background of adverse health effects from other sources in the veterinary and farming professions. The book examines adverse drug effects reported to regulatory agencies (mainly the FDA’s Center for Veterinary Medicine) and then considers a series of individual drugs, including antibiotics, anaesthetics and organophosphorus compounds. The chapters also discuss the fundamental aspects of regulatory issues relating to safety assessment, and examine the manner in which user safety is assessed prior to authorisation/approval and what measures can be taken after authorisation/approval in the light of findings from pharmacovigilance activities. There is growing concern over the issue of antimicrobial resistance and the contribution made by veterinary medicinal products. This too is addressed along with the significance to human health and measures that can be taken to mitigate the effects (if any) of the use of antibiotics in animals e.g. prudent use measures. The book will be an essential resource for medical practitioners in hospitals and general practice, pharmaceutical industry scientists, analysts, regulators and risk managers.

Patricia Frank, M. Alice Ottoboni, "The Dose Makes the Poison: A Plain-Language Guide to Toxicology, 3rd Edition"
English | ISBN: 0470381124 | 2011 | 284 pages

 This new edition of a widely-read and highly-acclaimed book broadens the scope of its predecessors from a heavy focus on industrial chemicals as toxicants to include drugs, food additives, cosmetics and other types of compounds that people are exposed to daily. Also new to the 3rd edition are newer issues-of-the-day such as nanoparticulate toxicants, second hand smoke, food contamination, lead in toys, and others. As such, the book provides the basics of toxicology in easy-to-understand language as well as a fuller understanding of the daily insults to which our bodies are subjected.

Effects of Persistent and Bioactive Organic Pollutants on Human Health by David O. Carpenter
2013 | ISBN: 1118159268 | English | 592 pages

Examines what we know about the relationship between organic chemicals and human disease

Organic chemicals are everywhere: in the air we breathe, the water we drink, and the food we eat. They are also found in a myriad of common household and personal care products. Unfortunately, exposure to some organic chemicals can result in adverse health effects, from growth and developmental disorders to cancer and neurodegenerative diseases. This book examines how organic chemicals affect human health. It looks at the different diseases as well as how individual organ systems are affected by organic chemicals.

Effects of Persistent and Bioactive Organic Pollutants on Human Health begins with an introductory chapter explaining why we should care about organic chemicals and their effect on human health. Next, the authors address such important topics as:

Burden of cancer from organic chemicals
Organic chemicals and obesity
Effects of organic chemicals on the male reproductive system
Organic chemicals and the immune system
Intellectual developmental disability syndromes and organic chemicals
Mental illness and exposure to organic chemicals
The book ends with an assessment of how much human disease is caused by organic chemicals. Chapters have been contributed by leading international experts in public and environmental health and are based on the latest research findings. Readers will find that all of the contributions are clear and easy to comprehend, with extensive references for further investigation of individual topics.

Effects of Persistent and Bioactive Organic Pollutants on Human Health is recommended for students and professionals in medicine as well as public and environmental health, bringing them fully up to date with what we know about the relationship between organic chemicals and human health.

Donald G. Barceloux - Medical Toxicology of Drug Abuse: Synthesized Chemicals and Psychoactive Plants
Published: 2012-03-20 | ISBN: 0471727601 | 

This book provides a broad reference covering important drugs of abuse including amphetamines, opiates, and steroids. It also covers psychoactive plants such as caffeine, peyote, and psilocybin. It provides chemical structures, analytical methods, clinical features, and treatments of these drugs of abuse, serving as a highly useful, in-depth supplement to a general medical toxicology book. The style allows for the easy application of the contents to searchable databases and other electronic products, making this an essential resource for practitioners in medical toxicology, industrial hygiene, occupational medicine, pharmaceuticals, environmental organizations, pathology, and related fields.
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