Analysis of Clinical Trials Using SAS: A Practical Guide English | ISBN:1590475046 | Feb 18, 2005 | 440 pages
This comprehensive guide bridges the gap between modern statistical methodology and real-world clinical trial applications. Step-by-step instructions illustrated with examples from actual trials and case studies serve to define a statistical method and its relevance in a clinical trials setting and to illustrate how to implement the method rapidly and efficiently using the power of SAS software.
Topics reflect the International Conference on Harmonization (ICH) guidelines for the pharmaceutical industry and address important statistical problems encountered in clinical trials, including analysis of stratified data, incomplete data, multiple inferences, issues arising in safety and efficacy monitoring, and reference intervals for extreme safety and diagnostic measurements. Clinical statisticians, research scientists, and graduate students in biostatistics will greatly benefit from the decades of clinical research experience compiled in this book. Numerous ready-to-use SAS macros and example code are included.
Clinical Epidemiology: The Essentials Fourth edition | March 7, 2005 | ISBN-10: 0781752159 | 288 pages
This introduction to epidemiology helps medical, nursing, and pharmacy students develop a system to observe and assess outcomes in similar patient types, and then apply this knowledge of outcomes to improve future patient care. The Fourth Edition has been redesigned to enhance understanding with new illustrations, pedagogical tools, examples, and summary boxes.
According to a faculty member at the University of North Carolina, "This is one of the few books truly written for students of clinical epidemiology...I've used it in the past and would do so in the future. The book is comprehensive and takes a practical approach to explaining important topics."
Thanos Athanasiou, H. Debas and Ara Darzi Publisher: Springer; 2010 edition (Feb 18, 2010) | ISBN: 3540719148 | English | 1018 pages
Key Topics in Surgical Research and Methodology represents a comprehensive reference text accessible to the surgeon embarking on an academic career. Key themes emphasize and summarize the text. Four key elements are covered, i.e. Surgical Research, Research Methodology, Practical Problems and Solutions on Research as well as Recent Developments and Future Prospects in Surgical Research and Practice.
Fundamentals of Clinical Trials, 4th edition
by Lawrence M. Friedman, Curt D. Furberg, David L. DeMets
English | 2010 | ISBN: 1441915850 | 408 pages
This is the fourth edition of a very successful textbook on clinical trials methodology, written by three recognized experts who have long and extensive experience in all areas of clinical trials. Most chapters have been revised considerably from the third edition. A chapter on ethics has been added and topics such as noninferiority and adaptive designs now receive considerable discussion. There is much new material on adverse events, adherence, data monitoring, and issues in analysis
"Medical Statistics fr om A to Z: A Guide for Clinicians and Medical Students" English | 2007-01-08 | ISBN: 0521867630 | 256 pages
Fr om 'Abcissa' to 'Zygosity determination' - this accessible introduction to the terminology of medical statistics describes more than 1500 terms all clearly explained, illustrated and defined in non-technical language, without any mathematical formulae! With the majority of terms revised and updated and the addition of more than 100 brand new definitions, this new edition will enable medical students to quickly grasp the meaning of any of the statistical terms they encounter when reading the medical literature. Furthermore, annotated comments are used judiciously to warn the unwary of some of the common pitfalls that accompany some cherished biomedical statistical techniques. Wh erever possible, the definitions are supplemented with a reference to further reading wh ere the reader may gain a deeper insight, so whilst the definitions are easily disgestible, they also provide a stepping stone to a more sophisticated comprehension. Statistical terminology can be quite bewildering for clinicians: this guide will be a lifesaver.
Manish Bhattacharjee, Sunil K. Dhar "Recent Advances in Biostatistics: False Discovery Rates, Survival Analysis, and Related Topics"
2011 | ISBN-10: 9814329797 | 312 pages
This unique volume provides self-contained accounts of some recent trends in Biostatistics methodology and their applications. It includes state-of-the-art reviews and original contributions.
The articles included in this volume are based on a careful selection of peer-reviewed papers, authored by eminent experts in the field, representing a well balanced mix of researchers from the academia, R&D sectors of government and the pharmaceutical industry.
The book is also intended to give advanced graduate students and new researchers a scholarly overview of several research frontiers in biostatistics, which they can use to further advance the field through development of new techniques and results.
Quality of Life Outcomes in Clinical Trials and Health-Care Evaluation: A Practical Guide to analysis and interpretation by Stephen J. Walters
English | 2009 | ISBN: 047075382X | 380 pages
An essential, up-to-date guide to the design of studies and selection of the correct QoL instruments for observational studies and clinical trials.
Quality of Life (QoL) outcomes or Person/Patient Reported Outcome Measures (PROMs) are now frequently being used in randomised controlled trials (RCTs) and observational studies. This book provides a practical guide to the design, analysis and interpretation of studies that use such outcomes.
QoL outcomes tend to generate data with discrete, bounded and skewed distributions. Many investigators are concerned about the appropriateness of using standard statistical methods to analyse QoL data and want guidance on what methods to use. QoL outcomes are frequently used in cross-sectional surveys and non-randomised health-care evaluations.
* Provides a user-friendly guide to the design and analysis of clinical trials and observational studies in relation to QoL outcomes.
* Discusses the problems caused by QoL outcomes and presents intervention options to help tackle them.
* Guides the reader step-by-step through the selection of appropriate QoLs.
* Features exercises and solutions and a supporting website providing downloadable data files.
Illustrated throughout with examples and case studies drawn from the author’s experience, this book offers statisticians and clinicians guidance on choosing between the numerous available QoL instruments.
MATLAB in bioscience and biotechnology By Leonid Burstein 2011 | 248 Pages | ISBN: 1907568042
In the last decade MATLAB has been presented to students as the first computer program they learn. Consequently, many non-programmer students, engineers and scientists have come to regard it as user-friendly and highly convenient in solving their specific problems. Numerous books are available on programming in MATLAB for engineers in general, irrespective of their specialization, or for those specializing in some specific area, but none have been designed especially for such a wide, interdisciplinary, and topical area as bioengineering.
The author presents an introductory MATLAB course oriented towards various collaborative areas of biotechnology and bioscience. The book concentrates on MATLAB fundamentals and gives examples of its application to a wide range of current bioengineering problems in computational biology, molecular biology, bio-kinetics, biomedicine, bioinformatics, and biotechnology. MATLAB is presented with examples and applications to various school-level and advanced bioengineering problems - from growing populations of microorganisms and population dynamics, reaction kinetics and reagent concentrations, predator-prey models, mass-transfer and flow problems, to sequence analysis and sequence statistics.
Using and Understanding Medical Statistics, 4th edition by David E. Matthews, Vernon T. Farewell
English | 2007 | ISBN: 3805581890 | 322 pages
Univ. of Waterloo, Canada. Presents many of the more complex statistical methods and techniques currently appearing in medical publications. This edition features new chapters on Poisson regression, the analysis of variance, meta-analysis, diagnostic tests, and more. For clinicians. Previous edition: c1996. Expanded-outline format. DNLM: Biometry-methods.
Francesco Chiappelli, Xenia Maria Caldeira Brant, Corazon B. Cajulis - Comparative Effectiveness and Efficacy Research and Analysis for Practice (CEERAP): Applications in Health Care
Published: 2012-05-04 | ISBN: 3642231438 | 206 pages
Recent trends in health care across the United States and internationally have emphasized a novel approach that consists in comparing the effectiveness and efficacy of treatment interventions with a patient-centered emphasis (i.e., evidence-based health care), while ensuring cost constraints, maximizing benefits, and minimizing risks. In this book, experts in comparative effectiveness and efficacy research and analysis for practice (CEERAP) in health care in general address a range of topical issues. The emphasis is on implications for endodontics and nursing, both of which are considered in a series of detailed chapters. Commonalities and differences among CEERAP, utility-based and logic-based analysis and decision-making, and evidence-based and patient-centered practice are defined and discussed. The book concludes by examining applications for CEERAP in developing patient-centered optimal treatment interventions for the next decade.
Jan Schildmann, Verena Sandow, Oliver Rauprich, Jochen Vollmann - Human Medical Research: Ethical, Legal and Socio-Cultural Aspects
Published: 2012-03-13 | ISBN: 3034803893 |203 pages
Medical research involving human subjects has contributed to considerable advancements in our knowledge, and to medical benefits. At the same time the development of new technologies as well as further globalisation of medical research raises questions that require the attention of researchers from a range of disciplines. This book gathers the contributions of researchers from nine different countries, who analyse recent developments in medical research from ethical, historical, legal and socio-cultural perspectives. In addition to reflections on innovations in science such as genetic databases and the concept of “targeted therapy” the book also includes analyses regarding the ethico-legal regulation of new technologies such as human tissue banking or the handling of genetic information potentially relevant for participants in medical research. Country and culture-specific aspects that are relevant to human medical research from a global perspective also play a part. The value of multi- and interdisciplinary analysis that includes the perspectives of scholars from normative and empirical disciplines is a shared premise of each contribution.
Statistical Analysis of Clinical Data on a Pocket Calculator
English | 2011 | ISBN: 9400712103 | 68 pages
The core principles of statistical analysis are too easily forgotten in today’s world of powerful computers and time-saving algorithms. This step-by-step primer takes researchers who lack the confidence to conduct their own analyses right back to basics, allowing them to scrutinize their own data through a series of rapidly executed reckonings on a simple pocket calculator. A range of easily navigable tutorials facilitate the reader’s assimilation of the techniques, while a separate chapter on next generation Flash prepares them for future developments in the field. This practical volume also contains tips on how to deny hackers access to Flash internet sites. An ideal companion to the author’s co-authored works on statistical analysis for Springer such as Statistics Applied to Clinical Trials, this monograph will help researchers understand the processes involved in interpreting clinical data, as well as being a necessary prerequisite to mastering more advanced statistical techniques. The principles of statistical analysis are easily forgotten in today’s world of time-saving algorithms. This step-by-step primer takes researchers back to basics, enabling them to examine their own data through a series of sums on a simple pocket calculator.
Cochrane Canada Live (webinars) http://ccnc.cochrane.org/cochrane-canada-live-webinars Cochrane Canada Live presents you with a variety of learning opportunities that you can experience online and at no charge.
Thursdays in June Cochrane 101: An Introduction to The Cochrane Collaboration
Thursday, 6 June 2013, 12 - 1PM EDT (Toronto); conducted in English Who was Cochrane? What is the Collaboration? And what are systematic reviews? Come learn about an international network that helps healthcare providers, policy-makers, patients, their advocates, and care-givers make well-informed decisions about health and health care. Hear how nearly 30,000 contributors work together to prepare, update, and disseminate Cochrane Reviews – and learn how you can join us!
The Steps of a Cochrane Review: An Overview
Thursday, 13 June 2013, 12 - 1PM EDT (Toronto); conducted in English What makes Cochrane Reviews different from other systematic reviews? Who – and what – is involved in the process? We will introduce you to the steps of a Cochrane Review and give you some practical tips for getting a review underway.
Let’s Start at the Very Beginning: Getting the Question Right for Your Cochrane Review
Thursday, 20 June 2013, 12 - 1PM EDT (Toronto); conducted in English A strong, clear question gives your Cochrane Review the foundation it needs: it informs your search strategy, narrows your focus, and provides the framework for your team’s work. Join us to learn what sort of questions are answered in Cochrane Reviews. We’ll cover the key components of a good research question and we’ll work through sample questions: you’re invited to share your research topic as an example!
Welcome to the Cochrane Colloquium! Tips and Tricks for Newcomers webinar Wednesday, 14 August 2013, 12-1PM EDT (Toronto); conducted in French Thursday, 15 August 2013, 12-1PM EDT (Toronto); conducted in English This webinar will provide a short introduction to The Cochrane Collaboration and some tips and tricks for making the most of your Colloquium experience. A Cochrane Colloquium is a unique international event from which you can benefit in many ways if you plan carefully: don’t miss any of the exciting opportunities to learn and collaborate! Hear from past participants about how to maximize your experience as a Colloquium newcomer.
2013 Methods Series Qualitative evidence synthesis and Cochrane reviews Thursday, 14 November 2013, 12-1PM EST (Toronto); conducted in English
This webinar will explore: a) when to consider undertaking a synthesis of qualitative evidence; b) some frequently used methods and examples of developing methods for synthesising qualitative evidence; and c) approaches for integrating qualitative and quantitative findings. Join Jane Noyes of the Cochrane Qualitative and Implementation Methods Group for the discussion.
Cochrane20 Video Series: video #11 released
As part of a series of events to mark The Cochrane Collaboration's 20th Anniversary, a series of videos has been commissioned focusing on the ideas, achievements and people that have contributed to the Collaboration's growth since 1993.
Every two weeks throughout 2013, one of a series of twenty-four short videos (5-10 minutes each), based around nearly a hundred interviews with Cochrane contributors from all over the world, will be released. The eleventh video, "Cochrane training", is now live on the Collaboration's YouTube channel, and on the 20th Anniversary website.http://anniversary.cochrane.org/
Qualitative Research in Physical Activity and the Health Professions by William Pitney, Jenny Parker 2009 | ISBN: 0736072136 | English | 232 Pages
Qualitative research is increasingly more common in the health professions, but most general research texts are limited in their discussion of the guiding principles of qualitative research. As a result, it is difficult for students and practitioners in the fields of athletic training, physical education, fitness, and health to sort out and apply the concepts involved in this method of research.
Qualitative Research in Physical Activity and the Health Professions puts to rest any confusion or misunderstanding about this type of research. The text clearly explains the underlying principles of qualitative inquiry, making it easy for students and practitioners to understand how to design, conduct, and evaluate qualitative research studies.
Written by two authors who have conducted numerous qualitative studies, taught graduate-level research courses, and advised many master's and doctoral students who have used qualitative methods in their pursuits, this text provides a focused approach to qualitative research for students and professionals in the physical activity and health care fields:
-Numerous pedagogical aids facilitate the learning process, including Learning Objectives, Dialogue Boxes that feature students' questions in a Q&A format, Take-Home Messages that summarize each chapter, Learning Activities that students may perform on their own time as an assignment, and Checking Your Knowledge sections that feature multiple-choice questions.
-The more familiar quantitative designs are contrasted with qualitative ones, making it easy for readers to follow the flow of information and make associations about how the two methods complement one another.
-Examples from current literature accentuate the essential components of an authentic qualitative research study, including observations, interviews, open-ended questions, and a format for analyzing data.
-Actual published articles are provided so that students can evaluate qualitative research methods.
Through Qualitative Research in Physical Activity and the Health Professions, readers learn how to frame a researchable problem, how to develop questions to gain insight that specifically applies to the problem, and how to guide the procedures for data collection and analysis.
The authors first present an overview of qualitative research and then explain the essential aspects of planning and designing the research. They address the modes of data collection and how to create a trustworthy study. They then discuss how to write qualitative research proposals and reports. Finally, they assist those who want to expand their knowledge of qualitative research by discussing the various forms and guiding readers in becoming good consumers of research. They also help readers deal with common challenges and criticisms of qualitative inquiry and provide suggested learning activities and supplemental reading. The result is a text that demystifies this very applicable type of research. Qualitative Research in Physical Activity and the Health Professions will greatly appeal to physical activity and health students and professionals alike as they seek to learn how to use qualitative research in their work.
Design and Analysis of Experiments, Special Designs and Applications (Volume 3) by Klaus Hinkelmann 2012 | ISBN: 0470530685 | English | 600 pages
Provides timely applications, modifications, and extensions of experimental designs for a variety of disciplines
Design and Analysis of Experiments, Volume 3: Special Designs and Applications continues building upon the philosophical foundations of experimental design by providing important, modern applications of experimental design to the many fields that utilize them. The book also presents optimal and efficient designs for practice and covers key topics in current statistical research.
Featuring contributions from leading researchers and academics, the book demonstrates how the presented concepts are used across various fields from genetics and medicinal and pharmaceutical research to manufacturing, engineering, and national security. Each chapter includes an introduction followed by the historical background as well as in-depth procedures that aid in the construction and analysis of the discussed designs. Topical coverage includes:
Genetic cross experiments, microarray experiments, and variety trials
Clinical trials, group-sequential designs, and adaptive designs
Fractional factorial and search, choice, and optimal designs for generalized linear models
Computer experiments with applications to homeland security
Robust parameter designs and split-plot type response surface designs
Analysis of directional data experiments
Throughout the book, illustrative and numerical examples utilize SAS®, JMP®, and R software programs to demonstrate the discussed techniques. Related data sets and software applications are available on the book's related FTP site.
Design and Analysis of Experiments, Volume 3 is an ideal textbook for graduate courses in experimental design and also serves as a practical, hands-on reference for statisticians and researchers across a wide array of subject areas, including biological sciences, engineering, medicine, and business.
Clinical Trials Handbook: Design and Conduct by Curtis L. Meinert English | 2012 | ISBN: 1118218469 | 600 pages
A systematic approach to all aspects of designing and conducting clinical trials
The success or failure of clinical trials hinges on hundreds of details that need to be developed, often under less than ideal conditions.
Written by one of the world's leading trialists, Clinical Trials Handbook: Design and Conduct provides clinicians with a complete guide to designing, conducting, and evaluating clinical trials—teaching them how to simplify the process and avoid costly mistakes.
The author draws on his extensive clinical trials experience to outline all steps employed in setting up and running clinical trials, from budgeting and fundraising to publishing the results. Along the way, practical advice is offered while also addressing a mix of logistical, ethical, psychological, behavioral, and administrative issues inherent to clinical trials. Topics of coverage include:
• Protocols for drug masking, controls, and treatment randomization
• Consent, enrollment, eligibility, and follow-up procedures
• Different types of sample size design and data collection and processing
• Working with study centers, research staff, and various committees
• Monitoring treatment effects and performance, and ensuring quality control
• Data analysis and access policies for study data and documents
Clinical Trials Handbook is invaluable for practicing clinicians and trialists who would like to learn more about or improve their understanding of the design and execution of clinical trials. The book is also an excellent supplement for courses on clinical trials at the graduate level.
Success Probability Estimation with Applications to Clinical Trials by Daniele De Martini 2013 | ISBN: 1118335783 | English | 232 pages
Provides an introduction to the various statistical techniques involved in medical research and drug development with a focus on estimating the success probability of an experiment
Success Probability Estimation with Applications to Clinical Trials details the use of success probability estimation in both the planning and analyzing of clinical trials and in widely used statistical tests.
Devoted to both statisticians and non-statisticians who are involved in clinical trials, Part I of the book presents new concepts related to success probability estimation and their usefulness in clinical trials, and each section begins with a non-technical explanation of the presented concepts. Part II delves deeper into the techniques for success probability estimation and features applications to both reproducibility probability estimation and conservative sample size estimation.
Success Probability Estimation with Applications to Clinical Trials:
• Addresses the theoretical and practical aspects of the topic and introduces new and promising techniques in the statistical and pharmaceutical industries
Features practical solutions for problems that are often encountered in clinical trials
Includes success probability estimation for widely used statistical tests, such as parametric and nonparametric models
Focuses on experimental planning, specifically the sample size of clinical trials using phase II results and data for planning phase III trials
Introduces statistical concepts related to success probability estimation and their usefulness in clinical trials
Success Probability Estimation with Applications to Clinical Trials is an ideal reference for statisticians and biostatisticians in the pharmaceutical industry as well as researchers and practitioners in medical centers who are actively involved in health policy, clinical research, and the design and evaluation of clinical trials.
Study design and statistical methodology are two important concerns for the clinical researcher. This book sets out to address both issues in a clear and concise manner. The presentation of statistical theory starts fr om basic concepts, such as the properties of means and variances, the properties of the Normal distribution and the Central Lim it Theorem and leads to more advanced topics such as maximum likelihood estimation, inverse variance and stepwise regression as well as, time-to-event, and event-count methods. Furthermore, this book explores sampling methods, study design and statistical methods and is organized according to the areas of application of each of the statistical methods and the corresponding study designs. Illustrations, working examples, computer simulations and geometrical approaches, rather than mathematical expressions and formulae, are used throughout the book to explain every statistical method.
Biostatisticians and researchers in the medical and pharmaceutical industry who need guidance on the design and analyis of medical research will find this book useful as well as graduate students of statistics and mathematics with an interest in biostatistics.
Provides clear explanations of key statistical concepts with a firm emphasis on practical aspects of design and analysis of medical research.
Features worked examples to illustrate each statistical method using computer simulations and geometrical approaches, rather than mathematical expressions and formulae.
Explores the main types of clinical research studies, such as, descriptive, analytical and experimental studies.
Addresses advanced modeling techniques such as interaction analysis and encoding by reference and polynomial regression.
Andrew B. Lawson, "Statistical Methods in Spatial Epidemiology, 2 edition"
English | ISBN: 0470014849 | 2006 | 424 pages
Spatial epidemiology is the description and analysis of the geographical distribution of disease. It is more important now than ever, with modern threats such as bio-terrorism making such analysis even more complex. This second edition of Statistical Methods in Spatial Epidemiology is upd ated and expanded to offer a complete coverage of the analysis and application of spatial statistical methods. The book is divided into two main sections: Part 1 introduces basic definitions and terminology, along with map construction and some basic models. This is expanded upon in Part II by applying this knowledge to the fundamental problems within spatial epidemiology, such as disease mapping, ecological analysis, disease clustering, bio-terrorism, space-time analysis, surveillance and infectious disease modelling.
Provides a comprehensive overview of the main statistical methods used in spatial epidemiology.
Updated to include a new emphasis on bio-terrorism and disease surveillance.
Emphasizes the importance of space-time modelling and outlines the practical application of the method.
Discusses the wide range of software available for analyzing spatial data, including WinBUGS, SaTScan and R, and features an accompanying website hosting related software.
Contains numerous data se ts, each representing a different approach to the analysis, and provides an insight into various modelling techniques.
This text is primarily aimed at medical statisticians, researchers and practitioners from public health and epidemiology. It is also suitable for postgraduate students of statistics and epidemiology, as well professionals working in government agencies.