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Форум » Другие медицинские вопросы » Медицинские ссылки » Иностранные ресурсы
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Фтизиатрия, детская и взрослая

The New Profile of Drug-Resistant Tuberculosis in Russia: A Global and Local Perspective
Summary of a Joint Workshop. Institute of Medicine; Russian Academy of Medical Sciences
NAS Press | 2011 | ISBN: 0309162971 9780309162975 | pages | PDF | 1 MB

This issue presents information from experts on the nature of this threat and how it can be addressed by exploring various treatment and diagnostic options.

An estimated 2 billion people, one third of the global population, are infected with Mycobacterium tuberculosis, the bacterium that causes tuberculosis. Spread through the air, this infectious disease killed 1.7 million in 2009, and is the leading killer of people with HIV. Tuberculosis (TB) is also a disease of poverty--the vast majority of tuberculosis deaths occur in the developing world.
Exacerbating the devastation caused by TB is the growing threat of drug-resistant forms of the disease in many parts of the world.
Drug-resistant tuberculosis presents a number of significant challenges in terms of controlling its spread, diagnosing patients quickly and accurately, and using drugs to treat patients effectively. In Russia in recent decades, the rise of these strains of TB, resistant to standard antibiotic treatment, has been exacerbated by the occurrence of social, political, and economic upheavals.
The Institute of Medicine (IOM) Forum on Drug Discovery, Development, and Translation, in conjunction with the Russian Academy of Medical Sciences held a workshop to discuss ways to fight the growing threat of drug-resistant TB.
Global tuberculosis report 2012
http://www.who.int/tb/publications/global_report/en/index.html
This is the seventeenth global report on tuberculosis (TB) published by WHO in a series that started in 1997. It provides a comprehensive and up-to-date assessment of the TB epidemic and progress in implementing and financing TB prevention, care and control at global, regional and country levels using data reported by 204 countries and territories that account for over 99% of the world’s TB cases.

H. Simon Schaaf MBChB

"Tuberculosis: A Comprehensive Clinical Reference"
Publisher: Saunders | 2009 | ISBN: 1416039880 | 1046 pages

This book provides all the vital information you need to know about tuberculosis, especially in the face of drug-resistant strains of the disease. Coverage includes which patient populations face an elevated risk of infection, as well as which therapies are appropriate and how to correctly monitor ongoing treatment so that patients are cured. Properly administer screening tests, interpret their results, and identify manifestations of the disease, with authoritative guidance from expert clinicians from around the world.
* Discusses screening tests for tuberculosis so you can interpret their results and identify not only common manifestations of the disease, but also those that are comparatively rare-such as tuberculosis in pregnant women.
* Covers all clinical aspects of tuberculosis in children, including current practices on managing those infected with HIV.
* Provides details on how best to interact with the public health system in both industrialized and developing countries.
* Addresses the social aspects of tuberculosis and presents the latest advances on new and potential vaccines against tuberculosis.
* Offers the expertise of internationally recognized tuberculosis clinicians to provide you with well-rounded, global coverage.
* Features numerous illustrations to provide clear and detailed depictions of rare manifestations of tuberculosis.

Peter D Davies, Peeter Barnes, Stephen B Gordon
"Clinical Tuberculosis"
Oxford University Press | 2008 | ISBN: 034094840X | 670 pages

Clinical Tuberculosis remains an indispensable resource for respiratory physicians, infectious disease specialists, public health workers and other individuals involved in the management and control of tuberculosis worldwide. This established reference is a comprehensive accoutn of tuberculosis, providing up-to-date and authoritative information on all aspects of the disease. It gives practical guidance to health professionals who may be involved in any aspect of patient management or disease control, including chapters on epidemiology, pathology, immunology, disease presentation, diagnosis, treatment and management options. Specific consideration is given to the problems of TB associated with HIV infection, and issues of control relating to low and high prevalence countries respectively. The ongoing issues surrounding the BCG vaccination and preventive therapy are also covered, as are the increasing problems of multi-drug resistant strains and environmental opportunist mycobacteria.

Henry Wouk, "Tuberculosis (Health Alert)"
English | ISBN: 076143979X | 2009 | 68 pages

Provides comprehensive information on the causes, treatment, and history of tuberculosis.

Tuberculosis and Nontuberculosis Mycobacterial Infections
MgH | 2005 | ISBN: 0071439137 | 400 pages

The Definitive Text on Tuberculosis Infections for More Than Two Decades!
This trusted resource provides infectious disease specialists with the most comprehensive coverage found anywhere of the varied manifestations of tuberculin diseases and the clinical options available to physicians for treating them.

AIDS and Tuberculosis: A Deadly Liaison
English | 2009 | ISBN: 3527322701 | 320 pages

The immune deficiency AIDS leads to a drastic increase in susceptibility to Tuberculosis.

Franz Joel Leong, Veronique Dartois, Thomas Dick, "A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis"
English | 2010 | ISBN: 1439835276 | 236 pages

An annual death toll of 2 million, coupled with rising drug resistance, highlights the need for the development of new drugs, better diagnostics, and a tuberculosis (TB) vaccine. Addressing these key issues, A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis introduces TB histopathology to the non-histopathologists, students, scientists, and doctors working, learning, and teaching in the field of TB. It contains 100 color photographs and illustrations that bring clarity to the information presented.

The atlas takes the unusual approach of covering multiple species histopathology, arguably the first and quite possibly the only resource to do so. It provides a simple, annotated, and visual presentation of the comparative histopathology of TB in human and animal models. The editors have compiled information that helps TB scientists to distinguish between the features of all major animal models available and to use them with their strengths and limitations in mind. The book provides guidance for selecting the best animal model(s) to answer specific questions and to test the efficacy of drug candidates.

"Tuberculosis: Current Issues in Diagnosis and Management" ed. by Bassam H. Mahboub and Mayank G. Vats
InTeOpP | 2013 | ISBN: 9535110491 9789535110491 | 500 pages

This book covers all cover all aspects and developments of the diagnosis and management of MDR TB in great detail. This book will serve as a practical guide for the diagnosis and management of TB for practicing physicians (especially pulmonologists and internists) and all those who are involved in the management of TB.

The book contains chapters on epidemiology, immune-pathology, diagnosis, treatment and latest advances for TB, highlighting the global perspective of tuberculosis.

Contents
Preface
Section 1 Pathophysiology and Immunogenesis of Tuberculosis
1 Mycobacterium tuberculosis Adaptation to Survival in a Human Host
2 The Immune Response to Mycobacterium tuberculosis Infection in Humans
3 Lipid Inclusions in Mycobacterial Infections
4 The Role of Antibodies in the Defense Against Tuberculosis
5 Influence of the Interferon-Gamma (IFN-y) and Tumor Necrosis Factor Alpha (TNF-a) Gene Polymorphisms in TB Occurrence and Clinical Spectrum
6 Tuberculosis Pharmacogenetics: State of The Art
7 Pathophysiology of Tuberculosis
Section 2 Diagnosis and Management of Tuberculosis
8 Laboratory Diagnosis of Tuberculosis - Latest Diagnostic Tools
9 Diagnostic Evaluation of Tuberculosis
10 First- and Second-Line Drugs and Drug Resistance
Section 3 Multi-Drug Resistant Tuberculosis
11 Epidemiology of Multidrug Resistant Tuberculosis (MDR-TB)
12 Drug Resistance in M. Tuberculosis
13 Management of Drug-Resistant TB
14 Drug-Resistant Tuberculosis - Diagnosis, Treatment. Management and Control: The Experience in Thailand
Section 4 Extra Pulmonary Tuberculosis
15 Tuberculous Pleural Effusion
16 Neurotuberculosis and HIV Infection
Section 5 Miscellaneous
17 Research and Development of New Drugs Against Tuberculosis
18 Web Resources on TB: Information. Research, and Data Analysis
19 Peadiatric Tuberculosis: Is the World Doing Enough?
20 Economic Evaluation of Diagnosis Tuberculosis in Hospital Setting
21 Pulmonary Tuberculosis in Latin America: Patchwork Studies Reveal Inequalities in Its Control - The Cases of Chiapas (Mexico), Chine (Ecuador) and Lima (Peru)

Tuberculosis: The White Plague! By Miriam Aronin
2010 | 36 Pages | ISBN: 1936088061

Oswaldo Juarez, a 19-year-old student in Florida, had been feeling ill for a few weeks. Then, on a fall night in 2007, he began to cough up blood. As he looked at the red stain in his sink, he thought he might be dying. He raced to a doctor to have tests done to find out what was wrong with him.
Then came the terrible news. Oswaldo had tuberculosis, or TB—a disease that kills more than one million people on Earth every year. How does this killer disease spread to so many people? Look inside to find out more about Oswaldo and other victims of tuberculosis. You’ll also discover what causes the dangerous illness, how it affects the body, and—most important—how to protect yourself from it in the first place.

"Understanding Tuberculosis - Deciphering the Secret Life of the Bacilli" ed. by Pere-Joan Cardona
InTeO | 2012 | ISBN: 9533079462 9789533079462 | 343 pages

In this book, different aspects of Mycobacterium tuberculosis properties are displayed by specialists in the field.

Mycobacterium tuberculosis, as recent investigations demonstrate, has a complex signaling expression, which allows its close interaction with the environment and one of its most renowned properties: the ability to persist for long periods of time under a non-replicative status. Although this skill is well characterized in other bacteria, the intrinsically very slow growth rate of Mycobium tuberculosis, together with a very thick and complex cell wall, makes this pathogen specially adapted to the stress that could be generated by the host against them.

Contents
Preface
Part 1 The "Quiet" Genome
1 Molecular Bio markers for Ancient Tuberculosis
2 Genomic Variability of Mycobacterium tuberculosis
3 IS6110 the Double-Edged Passenger
4 Response of Mycobacterial Species to an Acidic Environment
5 Mycobacterium Tuberculosis Signaling via c-AMP
6 Mycobacterium tuberculosis RD-1 Secreted Antigens as Protective and Risk Factors for Tuberculosis
7 Mycobacterium tuberculosis Transcriptome In Vivo Studies - A Key to Understand the Pathogen Adaptation Mechanism
Part 2 Resisting an Agressive Environment
3 Morphological Characterization of Mycobacterium tuberculosis
9 Mycobacterial Strains of Different Virulence Trigger Dissimilar Patterns of Immune System Activation In Vivo
10 Biofilms of Mycobacterium tuberculosis: New Perspectives of an Old Pathogen
11 Cell Wall Deficiency in Mycobacteria: Latency and Persistence
12 Mycobacterium tuberculosis: Dormancy. Persistence and Survival in the Light of Protein Synthesis
13 Lipid Surrounding of Mycobacteria: Lethal and Resuscitating Effects
14 Heat Shock Proteins in Mycobacterium tuberculosis: Involvement in Survival and Virulence of the Pathogen
15 Mammalian Heme Peroxidases and Mycobacterium tuberculosis
16 Thiol-Dependent Peroxidases in Mycobacterium tuberculosis Antioxidant Defense
17 Characteristic Conformational Behaviors of Representative Mycolic Acids in the Interfacial Monolayer


"Understanding Tuberculosis - New Approaches to Fighting Against Drug Resistance" ed. by Pere-Joan Cardona
InTeO | 2012 | ISBN: 9533079486 9789533079486 | 385 pages

In this book, diverse authors focus on the development and the activity of the new tuberculosis drug families.

In 1957, a Streptomyces strain, the ME/83 (S.mediterranei), was isolated in the Lepetit Research Laboratories from a soil sample collected at a pine arboretum near Saint Raphael, France. This drug was the base for the chemotherapy with Streptomicine. The euphoria generated by the success of this regimen lead to the idea that TB eradication would be possible by the year 2000.
Thus, any further drug development against TB was stopped. Unfortunately, the lack of an accurate administration of these drugs originated the irruption of the drug resistance in Mycobacterium tuberculosis. Once the global emergency was declared in 1993, seeking out new drugs became urgent.

Contents
Preface
Part 1 Strategies for new drug discovering
1 Multi-Drug/Extensively Drug Resistant Tuberculosis (Mdr/Xdr-Tb): Renewed Global Battle Against Tuberculosis?
2 Chemotherapeutic Strategies and Targets Against Resistant TB
3 A New Hope in TB Treatment: The Development of the Newest Drugs
4 In Search of El Dorado: Current Trends and Strategies in the Development of Novel Anti-Tubercular Drugs
5 An Approach to the Search for New Drugs Against Tuberculosis
6 Antitubercular In Vitro Drug Discovery: Tools for Begin the Search
7 New Antitubercular Drugs Designed by Molecular Modification
8 The Cord Factor: Structure, Biosynthesis and Application in Drug Research - Achilles Heel of Mycobacterium tuberculosis?
Part 2 New drugs to face Resistance
9 Old and New TB Drugs: Mechanisms of Action and Resistance
10 Pyrazinecarboxylic Acid Derivatives with Anti mycobacteria I Activity
11 The Potential Therapeutic Usage of Dithiocarbamate Sugar Derivatives for Multi-Drug Resistant Tuberculosis
12 Fighting Against Resistant Strains: The Case of Benzothiazinones and Dinitrobenzamides
13 Quinolone Resistance in Tuberculosis Treatment: A Structural Overview
14 Anti mycobacteria I Activity Some Different Lamiaceae Plant Extracts Containing Flavonoids and Other Phenolic Compounds
15 Cinnamic Derivatives in Tuberculosis
16 Potential Use of I. suffruticosa in Treatment of Tuberculosis with Immune System Activation

"Understanding Tuberculosis - Global Experiences and Innovative Approaches to the Diagnosis" ed. by Pere-Joan Cardona
InTeO | 2012 | ISBN: 9533079387 9789533079387 | 562 pages

This book presents the experience of worldwide specialists on the tuberculosis diagnosis, along with its lights and shadows.

Mycobacterium tuberculosis is a disease that is transmitted through aerosol. This is the reason why it is estimated that a third of humankind is already infected by Mycobacterium tuberculosis. The vast majority of the infected do not know about their status. Mycobacterium tuberculosis is a silent pathogen, causing no symptomatology at all during the infection. In addition, infected people cannot cause further infections. Unfortunately, an estimated 10 per cent of the infected population has the probability to develop the disease, making it very difficult to eradicate. Once in this stage, the bacilli can be transmitted to other persons and the development of clinical symptoms is very progressive.
Therefore the diagnosis, especially the discrimination between infection and disease, is a real challenge.

Contents
Part 1 Experience on Laboratory diagnosis around the World
1 Clinical Laboratory Diagnostics for Mycobacterium tuberculosis
2 Laboratory Diagnosis of Latent and Active Tuberculosis Infections in Trinidad a Tobago and Determination of Drug Susceptibility Profile of Tuberculosis Isolates in the Caribbean
3 Tuberculosis is Still a Major Challenge in Africa
4 Tuberculosis in Saudi Arabia
5 Diagnosis of Mycobacterium tuberculosis
6 Diagnosis of Smear-Negative Pulmonary Tuberculosis in Low-Income Countries: Current Evidence in Sub-Saharan Africa with Special Focus on HIV Infection or AIDS
7 Immunologic Diagnosis of Neurotuberculosis
8 Diagnostic Methods for Mycobacterium tuberculosis and Challenges in Its Detection in India
9 Management of TB in HIV Subjects, the Experience in Thailand
10 Mycobacterium tuberculosis: Biorisk, Biosafety and Biocontainment
Part 2 New approaches to the TB diagnosis
11 New Diagnostics for Mycobacterium tuberculosis
12 Nanodiagnostics for Tuberculosis
13 Sputum Smear Microscopy for Tuberculosis: Eval uation of Autofocus Functions and Automatic Identification of Tuberculosis Mycobacterium
14 The Use of Phage for Detection, Antibiotic Sensitivity Testing and Enumeration
15 Molecular Imaging in TB: From the Bench to the Clinic
16 Data Mining Techniques in the Diagnosis of Tuberculosis
17 Immunological Diagnosis of Active and Latent TB
18 Immune Diagnosis of Tuberculosis Through Novel Technologies
19 Exosomes: New Tuberculosis Bio markers - Prospects From the Bench to the Clinic
20 Molecular Techniques for Identification of Species of the Mycobacterium tuberculosis Complex: The use of Multiplex PCR and an Adapted HPLC Method for Identification of Mycobacterium bovis and Diagnosis of Bovine Tuberculosis
Part 3 Improving detection and control of resistances
21 Survey and Molecular Characterization of Drug- Resistant M. tuberculosis Clinical Isolates from Zunyi, Guizhou Province of China
22 Molecular Biological Techniques for Detection of Multidrug Resistant Tuberculosis (MDR) and Extremely Drug Resistant Tuberculosis (XDR) in Clinical Isolates of Mycobacterium tuberculosis
23 Detection of Mycobacterium tuberculosis and Drug Resistance: Opportunies and Challenges in Morocco
24 Pattern of Circulating Mycobacterium tuberculosis Strains in Sri Lanka
25 Health Interventions to Improve the Medication Efficacy in Tuberculosis Treatment

The Bioarchaeology of Tuberculosis: A Global View on a Reemerging Disease By Charlotte A. Roberts and Jane E. Buikstra
2003 | 368 Pages | ISBN: 0813026431 | PDF | 6 MB

"An excellent book on a topic of more than academic interest."--Anthropological Science

"Anyone interested in infectious diseases, however knowledgeable, will put down this book having learned something new. . . . Roberts and Buikstra have compiled what is for now the definitive work on the subject."--Journal of the History of Medicine

"Truly comprehensive in scope. . . . This remarkably well organized book is medical history at its best. . . . A fascinating reading adventure."--Choice

"This is not just an old bones book and the authors have sensibly outlined the social and environmental factors which need to be considered in any major survey of this kind. . . . Will remain a major reference work for decades to come."--Antiquity

Though apparently in decline during the first half of the 20th century, tuberculosis has reawakened in both developed and developing countries, particularly among susceptible populations with immunodeficiency disorders.
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